Diisobutylaluminumhydride → HCID 178441826, compound

Participants

Reaction Steps

The title compound can be prepared from 2-butyl-4-(N-methylacetamido)-1-(2'-(tetrazol-5-yl)-biphen-4-yl)methylimidazole-5-carboxylic acid by reaction with 3 molar equivalents of diisobutyl-aluminum hydride in THF at room temperature followed by aqueous workup (extraction from 0.1% aqueous HOAc with EtOAc and isolation (SiO2, 35:65:1 CH2Cl2 /MeOH/ NH4OH). Alternatively' the title compound could be prepared from 4-methylamino-5-benzyloxycarbonyl-2-butyl-1-(2'-(N-triphenylmethyltetrazol-5-yl-biphen-4-yl)methylimidazole (mentioned in Example 18, Step 2) by reaction as outlined in Example 18, Step 3.

Provenance & Evidence