HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → ethyl 5-amino-1-(4-fluorophenyl)-1H-pyrazole-4-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 4-Fluorophenylhydrazine hydrochloride | HCID 69981 | — |
| Reactant | 2-Propenoic acid, 2-cyano-3-ethoxy-, ethyl ester | HCID 78943 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | ethyl 5-amino-1-(4-fluorophenyl)-1H-pyrazole-4-carboxylate | HCID 688689 | 74% |
Reaction Steps
A stirred mixture of 11.38 g (70.0 mmole) of a commercially available sample of 4-fluorophenylhydrazine hydrochloride, 11.84 g (70.0 mmole) of ethyl (ethoxymethylene)cyanoacetate and 9.67 g (70.0 mmole) of potassium carbonate in 100 ml of ethanol was refluxed overnight and then treated with 300 ml of water. The precipitate was filtered and dried in vacuo to furnish 12.87 g (74% yield) of pale yellow crystalline solid. The sample was recrystallized from ethanol m.p. 151-2° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05064851 |
| Source dataset | uspto-grants-1991_11 |
| ORD ID | ord-f4f4fdc6111e4d59bd670b2040729ad3 |
| Source note | uspto-grants-1991_11 |