Ethyl Acetate → HCID 14529703, compound

Participants

Reaction Conditions

Reaction Steps

A solution is prepared from 339 mg of 4-(4-methoxy-3-trifluoromethanesulfonyloxyphenyl)-pyrrolidin-2-one in 9 ml of toluene and 4 ml of ethanol and stirred for 5 minutes under argon at room temperature with 38 mg of tetrakis(triphenylphosphine) palladium(0). After addition of 172 mg of m-methoxyphenylboronic acid and 1.3 ml of 2-molar sodium carbonate solution, the mixture is heated to 90° C. for 4 hours. After adding ethyl acetate and water, the organic phase is separated, washed neutral with saturated sodium chloride solution, dried over sodium sulfate, and concentrated. Recrystallization from alcohol/ethyl acetate/petroleum ether (40°-60° C.) yields 187 mg of compound having a melting point of 137°-139° C.

Provenance & Evidence