Diethyl Ether → HCID 19988333, compound

Participants

Reaction Steps

A mixture of 5.3 g of p-[p-(4-cyano-4-(2-methylbutyl)-cyclohexyl)-phenyl]-phenol (obtainable by alkaline ether cleavage from r-1-cyano-cis-4-(4'-propyloxybiphenyl-4-yl)-1-(2-methylbutyl)-cyclohexane with potassium tert.-butylate in NMP at 180°), 1.9 g of optically active 2-chloro-3-methyl-butyric acid and 170 g of DMAP are suspended in 40 ml of CH2Cl2. 3.1 g of DCC in 5 ml of CH2Cl2 are then added dropwise and the mixture is stirred at room temperature for 12 hours. After removal of the dicyclohexylurea and customary working up, optically active 4'-(4-cyano-4-(2-methylbutyl)-cyclohexyl)-biphenyl-4-yl 2-chloro-3-methyl-butyrate is obtained.

Provenance & Evidence