Sodium Methoxide → HCID 19988334, compound

HRID 973715Notes

Reaction equation

HRID 973715 reaction equation
[CH3:1][C@@H:2]([CH2:6][CH2:7][CH2:8][CH:9]([CH3:11])[CH3:10])[CH2:3][CH2:4]I.C[O-].[Na+].[F:15][C:16]1[CH:21]=[C:20]([C:22]2[CH:27]=[CH:26][C:25]([OH:28])=[CH:24][CH:23]=2)[CH:19]=[CH:18][C:17]=1[C:29]1[CH:34]=[CH:33][C:32]([OH:35])=[CH:31][CH:30]=1>CO>[F:15][C:16]1[CH:21]=[C:20]([C:22]2[CH:23]=[CH:24][C:25]([O:28][CH2:4][CH2:3][CH:2]([CH3:1])[CH2:6][CH2:7][CH2:8][CH:9]([CH3:11])[CH3:10])=[CH:26][CH:27]=2)[CH:19]=[CH:18][C:17]=1[C:29]1[CH:34]=[CH:33][C:32]([O:35][CH2:4][CH2:3][CH:2]([CH3:1])[CH2:6][CH2:7][CH2:8][CH:9]([CH3:11])[CH3:10])=[CH:31][CH:30]=1

Participants

5

Reactant 3

HCID 10942334Sodium MethoxideHCID 14203937HCID 14203937, compoundHCID 19988321HCID 19988321, compound

Product 1

HCID 19988334HCID 19988334, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

80.5 g (0.3 mol) of (S)-3,7-dimethyl-1-iodoctane are added dropwise to a solution of 16.2 g (0.3 mol) of sodium methylate and 24.8 g (0.1 mol) of 1-fluoro-2,5-di(4-hydroxyphenyl)-benzene in 150 ml of methanol at the boiling point. After 5 hours, the mixture is worked up in the customary manner. Recrystallization gives pure 1-fluoro-2,5-di-[4-(3,7-dimethyloctyloxy)-phenyl]-benzene.

Workup

  1. customRecrystallization

Sources & evidence

ORD record
ord-a97bd362e9e842388a52e5d85bb120cf
Source dataset
uspto-grants-1991_11
Patent number
US05064569

Reaction notes

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