Hydrochloric Acid → HCID 14751484, compound

Participants

Reaction Steps

A mixture of 8.12 g of the product of Step F, 80 ml of ethanol and 20.1 ml of ethanolic, 2N hydrogen chloride was refluxed with stirring for one hour and was evaporated to dryness under reduced pressure. The residue was washed with methylene chloride to obtain 6.7 g of the desired hydrochloride. A mixture of 6.7 g of the hydrochloride, 100 ml of ethanol and 3.2 g of sodium bicarbonate was refluxed with stirring for 4 hours and the mixture was filtered hot. The filtrate was evaporated to dryness under reduced pressure and the 6.05 g of residue was chromatographed over silica. Elution with a 98-2 methanol-ammonium hydroxide yielded 4.74 g of the desired product.

Provenance & Evidence