tert-butyl N-(4-aminobutyl)carbamate → HCID 14751511, compound

HRID 973720Notes

Reaction equation

HRID 973720 reaction equation
[F:1][C:2]([F:15])([F:14])[C:3]1[CH:4]=[C:5]([CH:11]=[CH:12][CH:13]=1)[O:6][CH2:7][C:8](Cl)=[O:9].[C:16]([O:20][C:21]([NH:23][CH2:24][CH2:25][CH2:26][CH2:27][NH2:28])=[O:22])([CH3:19])([CH3:18])[CH3:17]>C(Cl)(Cl)Cl>[C:16]([O:20][C:21]([NH:23][CH2:24][CH2:25][CH2:26][CH2:27][NH:28][C:8](=[O:9])[CH2:7][O:6][C:5]1[CH:11]=[CH:12][CH:13]=[C:3]([C:2]([F:15])([F:14])[F:1])[CH:4]=1)=[O:22])([CH3:19])([CH3:18])[CH3:17]

Participants

4

Reactant 2

HCID 4351tert-butyl N-(4-aminobutyl)carbamateHCID 13140641[3-(Trifluoromethyl)phenoxy]acetyl chloride

Product 1

HCID 14751511HCID 14751511, compoundYield 74.5%

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent2×

Procedure

A solution of 6.44 g of the product of Step C in 60 ml of chloroform was added at +10° C. to a solution of 10.2 g of N-(tert-butoxycarbonyl)-1,4-diamino-butane in 150 ml of chloroform and after stirring for 2 hours at room temperature, the mixture was evaporated to dryness under reduced pressure. The product was added to water and vacuum filtered to obtain 7.85 g of the desired product melting at 86° C.

Workup

  1. customthe mixture was evaporated to dryness under reduced pressure
  2. additionThe product was added to water and vacuum
  3. filtrationfiltered

Sources & evidence

ORD record
ord-89be0b69f07a492180d2a27770e416df
Source dataset
uspto-grants-1991_11
Patent number
US05064861

Reaction notes

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