tert-butyl N-(4-aminobutyl)carbamate → N-(tert-butoxycarbonyl)-N'-(1-naphthyl acetyl)-1,4-diamino-butane

関与物質

反応手順

A solution of 16.3 g of 1-naphthyl-acetic acid chloride in 80 ml of chloroform was added at +10° C. to a solution cooled to +10° C. of 15 g of N-(tert-butoxycarbonyl)-1,4-diamino butane, 100 ml of chloroform and 14 ml of triethylamine and after one hour of stirring at ambient temperature, the mixture was concentrated to dryness under reduced pressure. The residue was taken up in water, separated and dried under reduced pressure at 50° C. to obtain 27.8 g of the expected product.

情報源と証拠