Thionyl Chloride → (1-Naphthyloxy)acetyl chloride

HRID 973730Notes

Reaction equation

[C:1]1([O:11][CH2:12][C:13]([OH:15])=O)[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][CH:2]=1.S(Cl)([Cl:18])=O>>[C:1]1([O:11][CH2:12][C:13]([Cl:18])=[O:15])[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][CH:2]=1

Participants

Reactant 2

HCID 24386Thionyl Chloride

HCID 76313Naphthoxyacetic acid

Product 1

HCID 292530(1-Naphthyloxy)acetyl chloride

Procedure

10 g of naphthoxy-acetic acid and 60 ml of thionyl chloride were refluxed for 2 hours and after evaporating to dryness under reduced pressure, several distillations with benzene were carried out to obtain 11.16 g of the expected product which was used as is for Step B.

Workup

customafter evaporating to dryness under reduced pressure, several distillations with benzene

Sources & evidence

ORD record: ord-192744d7f9644c9ca63fa8163d00672f
Source dataset: uspto-grants-1991_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05064861

Reaction notes

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