Peracetic Acid → 4-BENZYLOXY-3-METHOXYPHENOL

HRID 973740Notes

Reaction equation

HRID 973740 reaction equation
[CH2:1]([O:8][C:9]1[CH:16]=[CH:15][C:12](C=O)=[CH:11][C:10]=1[O:17][CH3:18])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C(OO)(=[O:21])C>C(O)(=O)C>[CH2:1]([O:8][C:9]1[CH:16]=[CH:15][C:12]([OH:21])=[CH:11][C:10]=1[O:17][CH3:18])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 6585Peracetic AcidHCID 755064-(Benzyloxy)-3-methoxybenzaldehyde

Product 1

HCID 5626874-BENZYLOXY-3-METHOXYPHENOL

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent2×

Procedure

24.2 g of 4-benzyloxy-3-methoxy benzaldehyde (Beilst. Vol. 8, II p 283) were dissolved in 100 ml of acetic acid and a mixture of 25 ml of peracetic acid and 50 ml of acetic acid was added without exceeding 45° C. The mixture was stirred for 18 hours at +40° C. and after concentration to dryness, the residue was chromatographed on silica (eluant: hexane-ethyl acetate 8-2) to obtain 9.1 g of the expected product melting at 84° C.

Workup

  1. additionwas added
  2. customwithout exceeding 45° C
  3. concentrationafter concentration to dryness
  4. customthe residue was chromatographed on silica (eluant: hexane-ethyl acetate 8-2)

Sources & evidence

ORD record
ord-12d9a31a54d24a618926fefb7a7fdbe2
Source dataset
uspto-grants-1991_11
Patent number
US05064861

Reaction notes

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