HCID 178518408, compound → HCID 178518407, compound

Participants

Reaction Conditions

Reaction Steps

10 g of 2,6-dihydroxy-9-phenyl-8-purinethiol was dissolved in about 100 ml 1N sodium hydroxide followed by addition of about 30 g Raney nickel. Slight foaming occurred. The reaction was slowly heated to reflux (oil bath about 120° C.). After 1.5 hours the reaction was filtered. The filtrate was cooled to about 4° C. and filtered. The white solid was dissolved in hot water treated with charcoal, filtered and treated with concentrated hydrochloric acid to produce a white precipitate. This was filtered, dried under vacuum at 80° C. for three hours to yield 3.3 g of 2,6-dihydroxy-9-phenylpurine (38% yield).

Provenance & Evidence