HCID 178518408, compound → HCID 178518407, compound

Participants

Reaction Conditions

Reaction Steps

2.5 g of 2,6-dihydroxy-9-phenyl-8-purinethiol was dissolved in 250 ml 1N sodium hydroxide and treated with 75 g Raney nickel. It was then heated to reflux for 2 hours and then filtered through Celite while hot. The filtrate was cooled to about 4° C., the white precipitate collected, dissolved in hot water, treated with charcoal, filtered, cooled in an ice bath and acidified with concentrated hydrochloric acid. The white product was collected and dried under vacuum at 70° C. for 2 days to yield 11.3 g of 2,6-dihydroxy-9-phenylpurine.

Provenance & Evidence