Potassium Hydroxide → HCID 178524740, compound

HRID 973815Notes

Reaction equation

HRID 973815 reaction equation
C([O:3][C:4]([C:6]1[CH:7]=[N:8][C:9]2[N:10]([N:13]=[CH:14][N:15]=2)[C:11]=1[SH:12])=[O:5])C.[OH-].[K+]>>[C:4]([C:6]1[CH:7]=[N:8][C:9]2[N:10]([N:13]=[CH:14][N:15]=2)[C:11]=1[SH:12])([OH:5])=[O:3]

Participants

3

Reactant 2

HCID 14797Potassium HydroxideHCID 178469694HCID 178469694, compound

Product 1

HCID 178524740HCID 178524740, compoundYield 95.2%

Procedure

The product obtained in Step 2 (2.4 g) was dissolved in 50 ml of aqueous solution containing 1.0 g. potassium hydroxide, the solution was heated at 80° C. for one hour, the insoluble matters were filtered off, and the clear, faint yellow filtrate was washed with 30 ml ethyl acetate. The pH of the aqueous layer was lowered to 1.0 with concentrated hydrochloric acid, and the crystals thus formed were collected by filtration, affording 2.0 g of the objective compound as colorless crystals.

Workup

  1. additioncontaining 1.0 g
  2. filtrationthe insoluble matters were filtered off
  3. washthe clear, faint yellow filtrate was washed with 30 ml ethyl acetate
  4. customthe crystals thus formed
  5. filtrationwere collected by filtration

Sources & evidence

ORD record
ord-93fcc3dbd4f54627a72ac8e0238fcb38
Source dataset
uspto-grants-1991_11
Patent number
US05064953

Reaction notes

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