Sodium hydrosulfide → HCID 178470728, compound

HRID 973821Notes

Reaction equation

HRID 973821 reaction equation
Cl[C:2]1[N:7]2[N:8]=[CH:9][N:10]=[C:6]2[N:5]=[C:4]([CH2:11][C:12]([O:14][CH2:15][CH3:16])=[O:13])[CH:3]=1.[SH-:17].[Na+]>O>[CH2:15]([O:14][C:12]([CH2:11][C:4]1[CH:3]=[C:2]([SH:17])[N:7]2[N:8]=[CH:9][N:10]=[C:6]2[N:5]=1)=[O:13])[CH3:16]

Participants

4

Reactant 2

HCID 28015Sodium hydrosulfideHCID 19989192HCID 19989192, compound

Product 1

HCID 178470728HCID 178470728, compoundYield 92.6%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

The product obtained in Step 2 (24 g) was added all at once, under a nitrogen stream, to a solution of 23 g sodium hydrosulfide in 600 ml of water, the mixture was stirred at room temperature for two hours, and the insoluble matters were filtered off. The filtrate was acidified to pH 2.0 with concentrated hydrochloric acid, and the crystals thus formed were collected by filtration, washed twice with 40 ml of water and dried, affording 22 g of the objective compound as yellow crystals.

Workup

  1. filtrationthe insoluble matters were filtered off
  2. customthe crystals thus formed
  3. filtrationwere collected by filtration
  4. washwashed twice with 40 ml of water
  5. customdried

Sources & evidence

ORD record
ord-064aa4a5463d4973b2cd15896efc1c94
Source dataset
uspto-grants-1991_11
Patent number
US05064953

Reaction notes

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