HCID 178469413, compound → HCID 178524653, compound

Participants

Reaction Conditions

Reaction Steps

The product obtained in Step 2 (2.0 g) was dissolved in a solution of 1.0 g potassium hydroxide in 80 ml of water, the mixture was heated at 80° C. for 30 minutes. After cooling the resulting orange solution to room temperature, it was washed with 50 ml of ethyl acetate, the pH of the aqueous layer was lowered to 1.0 with 6N hydrochloric acid, and the crystals thus formed were collected by filtration, washed with 50 ml of acetone, giving 1.6 g of the objective compound as orange crystals.

Provenance & Evidence