HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → HCID 178499043, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Methyl 5-amino-1H-1,2,4-triazole-3-carboxylate | HCID 77201 | — |
| Reactant | Ethyl isobutyrylacetate | HCID 81583 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | HCID 178499043 | HCID 178499043 | 55.6% |
Reaction Steps
A mixture of 3-amino-5-methoxycarbonyl-s-triazole (60 g) and ethyl 3-oxo-4-methylvalerate (65 g) in 600 ml of acetic acid was refluxed for five hours, the reaction mixture was cooled to room temperature, its pH was lowered to 1 to 2 with concentrated hydrochloric acid, and the separated crystals were recrystallized from ethanol, affording 54 g of the objective compound as colorless crystals.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05064953 |
| Source dataset | uspto-grants-1991_11 |
| ORD ID | ord-16fda21aaf6b4bf7adb5a27535924f20 |
| Source note | uspto-grants-1991_11 |