Cortisol → HCID 178441396, compound

HRID 973881Notes

Reaction equation

[CH3:1][CH2:2][CH2:3][CH2:4][CH:5]1[C:40](=[O:41])[O:39][CH:38]([CH:42]([CH:44]([OH:52])[CH2:45][CH2:46][CH2:47][NH:48][C:49]([NH2:51])=[NH:50])[CH3:43])[CH:37]([CH3:53])[CH:36]=[C:35]([CH3:54])[CH2:34][CH2:33][CH2:32][CH2:31][CH:30]([OH:55])[CH2:29][CH:28]([OH:56])[CH2:27][CH:26]([OH:57])[CH2:25][CH:24]([OH:58])[CH2:23][CH:22]([OH:59])[CH:21]([O:60][C@H:61]2[O:65][C@H:64]([CH2:66][OH:67])[C@@H:63]([OH:68])[C@@H:62]2[OH:69])[CH:20]=[C:19]([CH3:70])[CH:18]([OH:71])[CH2:17][CH2:16][CH2:15][CH:14]([OH:72])[CH2:13][CH2:12][CH2:11][CH:10]([OH:73])[CH2:9][CH2:8][CH:7]([CH3:74])[CH:6]1[OH:75].[CH3:76][C@@H:77]1[C@@H:116]([OH:117])[C@@H:115]([CH3:118])[C@H:114]([CH3:119])[O:113][C:111](=[O:112])[CH2:110][C@H:109]([OH:120])[CH2:108][C@H:107]([OH:121])[CH2:106][C@H:105]([OH:122])[CH2:104][CH2:103][C@@H:102]([OH:123])[C@H:101]([OH:124])[CH2:100][C@@:98]2([OH:125])[O:99][C@H:94]([C@H:95]([C:127]([OH:129])=[O:128])[C@@H:96]([OH:126])[CH2:97]2)[CH2:93][C@@H:92]([O:130][C@H:131]2[O:136][C@@H:135]([CH3:137])[C@H:134]([OH:138])[C@@H:133]([NH2:139])[C@H:132]2[OH:140])[CH:91]=[CH:90][CH:89]=[CH:88][CH:87]=[CH:86][CH:85]=[CH:84][CH2:83][CH2:82][CH:81]=[CH:80][CH:79]=[CH:78]1.[CH3:141][C@@:142]12[C@H:152]3[C@@H:153]([OH:166])[CH2:154][C@:155]4([CH3:165])[C@@:159]([OH:164])([C:160]([CH2:162][OH:163])=[O:161])[CH2:158][CH2:157][C@H:156]4[C@@H:151]3[CH2:150][CH2:149][C:148]1=[CH:147][C:145](=[O:146])[CH2:144][CH2:143]2>>[CH3:1][CH2:2][CH2:3][CH2:4][CH:5]1[C:40](=[O:41])[O:39][CH:38]([CH:42]([CH:44]([OH:52])[CH2:45][CH2:46][CH2:47][NH:48][C:49]([NH2:51])=[NH:50])[CH3:43])[CH:37]([CH3:53])[CH:36]=[C:35]([CH3:54])[CH2:34][CH2:33][CH2:32][CH2:31][CH:30]([OH:55])[CH2:29][CH:28]([OH:56])[CH2:27][CH:26]([OH:57])[CH2:25][CH:24]([OH:58])[CH2:23][CH:22]([OH:59])[CH:21]([O:60][C@H:61]2[O:65][C@H:64]([CH2:66][OH:67])[C@@H:63]([OH:68])[C@@H:62]2[OH:69])[CH:20]=[C:19]([CH3:70])[CH:18]([OH:71])[CH2:17][CH2:16][CH2:15][CH:14]([OH:72])[CH2:13][CH2:12][CH2:11][CH:10]([OH:73])[CH2:9][CH2:8][CH:7]([CH3:74])[CH:6]1[OH:75].[CH3:141][C@@:142]12[C@H:152]3[C@@H:153]([OH:166])[CH2:154][C@:155]4([CH3:165])[C@@:159]([OH:164])([C:160]([CH2:162][OH:163])=[O:161])[CH2:158][CH2:157][C@H:156]4[C@@H:151]3[CH2:150][CH2:149][C:148]1=[CH:147][C:145](=[O:146])[CH2:144][CH2:143]2.[CH3:76][C@@H:77]1[C@@H:116]([OH:117])[C@@H:115]([CH3:118])[C@H:114]([CH3:119])[O:113][C:111](=[O:112])[CH2:110][C@H:109]([OH:120])[CH2:108][C@H:107]([OH:121])[CH2:106][C@H:105]([OH:122])[CH2:104][CH2:103][C@@H:102]([OH:123])[C@H:101]([OH:124])[CH2:100][C@@:98]2([OH:125])[O:99][C@H:94]([C@H:95]([C:127]([OH:129])=[O:128])[C@@H:96]([OH:126])[CH2:97]2)[CH2:93][C@@H:92]([O:130][C@H:131]2[O:136][C@@H:135]([CH3:137])[C@H:134]([OH:138])[C@@H:133]([NH2:139])[C@H:132]2[OH:140])[CH:91]=[CH:90][CH:89]=[CH:88][CH:87]=[CH:86][CH:85]=[CH:84][CH2:83][CH2:82][CH:81]=[CH:80][CH:79]=[CH:78]1

Participants

Reactant 3

HCID 5754Cortisol

HCID 444248381400-61-9

HCID 178441392HCID 178441392, compound

Product 1

HCID 178441396HCID 178441396, compound

Procedure

From 20 g of Primycin and 40.0 g of N-methyl-pyrrolidone-2 a gel is prepared at 70° C., whereupon nystatin and hydrocortisone are added at room temperature under constant stirring. A very viscous solution is obtained which becomes gelous on standing for 24 hours.

Workup

additionare added at room temperature under constant stirring
customA very viscous solution is obtained which

Sources & evidence

ORD record: ord-b01e97983ae342f2a6a3246acefdddf6
Source dataset: uspto-grants-1991_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05064815

Reaction notes

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