HCID 178441398, compound → HCID 178441392, compound

HRID 973882Notes

Reaction equation

HRID 973882 reaction equation
[CH3:1][CH2:2][CH2:3][CH2:4][CH:5]1[C:40](=[O:41])[O:39][CH:38]([CH:42]([CH:44]([OH:52])[CH2:45][CH2:46][CH2:47][NH:48][C:49]([NH2:51])=[NH:50])[CH3:43])[CH:37]([CH3:53])[CH:36]=[C:35]([CH3:54])[CH2:34][CH2:33][CH2:32][CH2:31][CH:30]([OH:55])[CH2:29][CH:28]([OH:56])[CH2:27][CH:26]([OH:57])[CH2:25][CH:24]([OH:58])[CH2:23][CH:22]([OH:59])[CH:21]([O:60][C@H:61]2[O:65][C@H:64]([CH2:66][OH:67])[C@@H:63]([OH:68])[C@@H:62]2[OH:69])[CH:20]=[C:19]([CH3:70])[CH:18]([OH:71])[CH2:17][CH2:16][CH2:15][CH:14]([OH:72])[CH2:13][CH2:12][CH2:11][CH:10]([OH:73])[CH2:9][CH2:8][CH:7]([CH3:74])[CH:6]1[OH:75].C[C@@]12[C@H]3[C@@H](O)C[C@]4(C)[C@@](O)(C(CO)=O)CC[C@H]4[C@@H]3CCC1=CC(=O)CC2.C[C@@H]1[C@@H](O)[C@@H](C)[C@H](C)OC(=O)C[C@H](O)C[C@H](O)C[C@H](O)CC[C@@H](O)[C@H](O)C[C@@]2(O)O[C@H]([C@H](C(O)=O)[C@@H](O)C2)C[C@@H](O[C@H]2O[C@@H](C)[C@H](O)[C@@H](N)[C@H]2O)C=CC=CC=CC=CCCC=CC=C1.CN1C(=O)CCC1>O>[CH3:1][CH2:2][CH2:3][CH2:4][CH:5]1[C:40](=[O:41])[O:39][CH:38]([CH:42]([CH:44]([OH:52])[CH2:45][CH2:46][CH2:47][NH:48][C:49]([NH2:51])=[NH:50])[CH3:43])[CH:37]([CH3:53])[CH:36]=[C:35]([CH3:54])[CH2:34][CH2:33][CH2:32][CH2:31][CH:30]([OH:55])[CH2:29][CH:28]([OH:56])[CH2:27][CH:26]([OH:57])[CH2:25][CH:24]([OH:58])[CH2:23][CH:22]([OH:59])[CH:21]([O:60][C@H:61]2[O:65][C@H:64]([CH2:66][OH:67])[C@@H:63]([OH:68])[C@@H:62]2[OH:69])[CH:20]=[C:19]([CH3:70])[CH:18]([OH:71])[CH2:17][CH2:16][CH2:15][CH:14]([OH:72])[CH2:13][CH2:12][CH2:11][CH:10]([OH:73])[CH2:9][CH2:8][CH:7]([CH3:74])[CH:6]1[OH:75]

Participants

3

Reactant 1

HCID 178441398HCID 178441398, compound

Product 1

HCID 178441392HCID 178441392, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent2×

Procedure

The alcohol cetyl stearilicus and emulsifier E 2155 (stearyl alcohol polyglycol ether, manufacturer: T. Goldschmidt, Essen, GFR) are melted on a water-bath under constant stirring at 60°-70° C. About 80% of the distilled water having the same temperature is added under constant stirring in a thin stream. The gel is further homogenized with the previously prepared primycin+hydrocortisone+nystatin NMP gel and finally filled up with distilled water.

Workup

  1. customare melted on a water-bath
  2. stirringunder constant stirring in a thin stream

Sources & evidence

ORD record
ord-faab99dacc9a4ba3b167792504534b98
Source dataset
uspto-grants-1991_11
Patent number
US05064815

Reaction notes

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