Chlorosuccinimide → HCID 19987104, compound

Participants

Reaction Conditions

Reaction Steps

To a solution containing 20 g of 6-chloro-3-(2-ethylhexyl)-1-methyluracil thus-obtained in 50 ml of acetonitrile was added 8.6 g of N-chlorosuccinimide, the mixture was heated to 40° C. and stirred for 2 hours. After allowing the mixture to cool, the acetonitrile was distilled off under reduced pressure, to the residue was added water and it was extracted with 100 ml of chloroform. The organic phase was washed with a saturated aqueous sodium chloride solution and dried with anhydrous magnesium sulfate. The chloroform was distilled off under reduced pressure, and the residue was purified by silica gel chromatography to obtain 22 g of 5,6-dichloro-3-(2-ethylhexyl)-1-methyluracil as an oily product.

Provenance & Evidence