Ammonia → 2-Amino-4-chlorobenzamide

HRID 973914Notes

Reaction equation

HRID 973914 reaction equation
Cl[C:2]1[CH:10]=[C:9]([Cl:11])[CH:8]=[CH:7][C:3]=1[C:4]([NH2:6])=[O:5].[NH3:12]>>[NH2:12][C:2]1[CH:10]=[C:9]([Cl:11])[CH:8]=[CH:7][C:3]=1[C:4]([NH2:6])=[O:5]

Participants

3

Reactant 2

HCID 222AmmoniaHCID 755562,4-Dichlorobenzamide

Product 1

HCID 123748372-Amino-4-chlorobenzamide

Procedure

190 g of 2,4-dichlorobenzamide was dissolved in 1.5 liters of aqueous ammonia, and to the resulting solution was added 100 g of cuprous chloride. The mixture was reacted at 80° C. for 15 hours in an autoclave, and then neutralized. The crystals deposited were collected by filtration. Yield: 122 g (71.5%)

Workup

  1. customThe mixture was reacted at 80° C. for 15 hours in an autoclave
  2. filtrationThe crystals deposited were collected by filtration

Sources & evidence

ORD record
ord-70f469c15fe2496a9d058d1f1845b271
Source dataset
uspto-grants-1991_11
Patent number
US05066577

Reaction notes

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