Acetic Anhydride → HCID 19360204, compound

HRID 973916Notes

Reaction equation

HRID 973916 reaction equation
[NH2:1][C:2]1[CH:9]=[C:8]([Cl:10])[CH:7]=[CH:6][C:3]=1[C:4]#[N:5].[C:11](OC(=O)C)(=[O:13])[CH3:12]>C(#N)C>[C:11]([NH:1][C:2]1[CH:9]=[C:8]([Cl:10])[CH:7]=[CH:6][C:3]=1[C:4]#[N:5])(=[O:13])[CH3:12]

Participants

4

Reactant 2

HCID 7918Acetic AnhydrideHCID 170059Benzonitrile, 2-amino-4-chloro-

Product 1

HCID 19360204HCID 19360204, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

To 100 ml of acetonitrile were added 30 g of 2-amino-4-chlorobenzonitrile obtained in Step (2) and then 30 ml of acetic anhydride, and the mixture was refluxed by heating. After the completion of the reaction, the solvent was distilled off, then to the residue was added 500 ml of water, and the crystals thus-deposited were collected by filtration, washed with water and dried. Yield: 29 g (75.6%).

Workup

  1. temperatureby heating
  2. customAfter the completion of the reaction
  3. distillationthe solvent was distilled off
  4. additionto the residue was added 500 ml of water
  5. filtrationthe crystals thus-deposited were collected by filtration
  6. washwashed with water
  7. customdried

Sources & evidence

ORD record
ord-b2e37e7b29444e238590fa181ecb8a36
Source dataset
uspto-grants-1991_11
Patent number
US05066577

Reaction notes

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