Morpholine → HCID 53974378, compound

Participants

Reaction Steps

4.84 g (0.02 moles) of 3-pyroglutamyl-thiazolidine-4-carboxylic acid are suspended in 20 ml of DMF and treated with 3.25 g (0.02 mole) of carbonyldiimidazole. After no more gas is developed, 1.72 g (0.02 moles) of morpholine dissolved in 10 ml of DMF is added thereto and shaken for 1 hour. After diluting with 2 volumes of ethyl ether, the solid is filtered and water recrystallized yielding 4.35 g (70%) of product. m.p. 187°-188° C.

Provenance & Evidence