HuagongsheHuagongshe Chemistry Print Report · For research reference only
2,3-Dihydroxybutanedioic Acid → HCID 13891198, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2,3-Dihydroxybutanedioic Acid | HCID 875 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | Ethyl (3R,4S)-4-[[(1,1-dimethylethoxy)carbonyl]amino]-2,2-difluoro-3-hydroxy-6-methylheptanoate | HCID 13893282 | — |
| Solvent | Methanol--water (1/1) | HCID 22242641 | — |
| Product | HCID 13891198 | HCID 13891198 | — |
Reaction Steps
1 g N--BOC--(4S,3R)-2,2-difluorostatine ethyl ester is dissolved in methanol/water and reacted with 0.25 g of concentrated aqueous sodium hydroxide. After 2 hours the mixture is made acidic with 2N tartaric acid solution and extracted with ethyl acetate. The organic phase is dried over magnesium sulfate and evaporated to dryness. N--BOC--(4S,3R)-2,2-difluorostatine is obtained (crude).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05066643 |
| Source dataset | uspto-grants-1991_11 |
| ORD ID | ord-b9c92a757000415a93138fafc09cebff |
| Source note | uspto-grants-1991_11 |