HCID 15027469, compound → 2-(4-Chlorophenyl)-3-[(pyridin-2-yl)methyl]-3H-imidazo[4,5-b]pyridine

Participants

Reaction Steps

A solution of 4-chloro-N-[2-[(2-pyridinylmethyl)amino]-3-pyridinyl]benzamide (14.65 g, 0.0433 mol) prepared in the previous paragraph and ethylene glycol (145 mL) were heated at reflux for 1.5 hr and then stirred at room temperature overnight. The resulting solid was collected by filtration, rinsed several times with water, recrystallized from isopropanol/water and dried under high vacuum at 70° C. to give 10.36 g (74% yield) of the title compound, mp 144°-146° C.

Provenance & Evidence