反应详情

A stirred mixture of 7-amino-[5H]indeno[1,2-c]-pyridazin-3(2H)-one hydrochloride (1.0 g) and 4H-pyran-4-one (0.48 g) in water (10 ml) was heated under reflux for 1 hour in a nitrogen atmosphere. The warm mixture was neutralised with aqueous ammonia to give a solid, 0.9 g, m.p. >300° C. This solid was triturated with warm dilute hydrochloric acid and washed with water to give the title compound, 0.42 g m.p. >300° C.

1. temperaturewas heated
2. temperatureunder reflux for 1 hour in a nitrogen atmosphere
3. customto give a solid, 0.9 g, m.p. >300° C
4. customThis solid was triturated
5. temperaturewith warm dilute hydrochloric acid
6. washwashed with water