HCID 15020473, compound → HCID 15020474, compound

Participants

Reaction Steps

Potassium thioacetate (3.3 g, 0.029 mol) and 3.0 g (0.0145 mol) of 3-ethyl-4-(3-pyridazinylmethyl)-2-pyrrolidinone (Example 1) are stirred for 6 hours at 150° C. in 50 mL of dimethylformamide. After cooling and evaporating the solvent, the residue is dissolved in 95% methylene chloride/methanol, washed twice with saturated sodium bicarbonate solution and once with water. After drying the organic phase with sodium sulphate, the mixture is filtered and concentrated by evaporation. The product is purified by chromatography in silica gel to give the title compound.

Provenance & Evidence