Water → HCID 19987311, compound

Participants

Reaction Steps

A solution of the product of stage (ii) (650 mg) in ethanolic hydrogen chloride was hydrogenated over pre-reduced 10% palladium on carbon (0.20 g of a 50% w/w paste with water) at 25° and atmospheric pressure for 24 h. The catalyst was removed by filtration and the solvent evaporated in vacuo to give a foam. The residue was purified by flash column chromatography eluting with dichloromethane:ethanol:0.88 ammonia (50:8:1). Evaporation of the solvent in vacuo from the appropriate fractions gave the title compound as a foam (188 mg).

Provenance & Evidence