反应详情

21.5 g of 2-hydroxypropiophenone and 20.6 g of picolinic acid hydrazide are stirred in 250 ml of ethyl cellosolve for 18 hours at 110° C. and then for 2 hours at room temperature. The light yellow solution is concentrated on a rotary evaporator to approx. 50% of its volume. The yellow crystals which have precipitated are isolated by filtration and washed with isopropanol and then with water. After the crystals have been dried under vacuum at 50° C., 18 g of 2-hydroxypropiophenone picolinoylhydrazone are obtained which gives the following microanalysis:

1. concentrationThe light yellow solution is concentrated on a rotary evaporator to approx. 50% of its volume
2. customThe yellow crystals which have precipitated
3. customare isolated by filtration
4. washwashed with isopropanol
5. customAfter the crystals have been dried under vacuum at 50° C.