Isoniazid → HCID 178465645, compound

Participants

Reaction Steps

20.3 g of 3-acetyl-2,4-dihydroxyquinoline and 13.8 g of isonicotinic acid hydrazide are condensed in 180 ml of ethyl cellosolve analogously to Example 1, yielding 27.2 g of 3-acetyl-2,4-dihydroxyquinoline isonicotinoylhydrazone. 3.2 g of this product are suspended in 25 ml of dimethylformamide and treated with a solution of 2.7 g of nickel(II) acetate·4H2O in dimethylformamide. The resulting mixture is stirred for 2 hours at 80°-90° C. and the product is then isolated by filtration and subsequently washed with isopropanol and then with water. After the product has been dried under vacuum at 70°-80° C., 3.5 g of a yellow powder of the following formula: ##STR23## as the 1:1 nickel complex, are obtained which gives the following microanalysis:

Provenance & Evidence