4-Hydroxybiphenyl → HCID 15675493, compound

Participants

Reaction Steps

By the method of Example 34, 7-([1,1'-biphenyl]-4-yloxy)-heptanenitrile was prepared from 7-bromoheptanenitrile and 4-phenylphenol, as shiny flakes from water-methanol, mp 78°-79° C. This material (3.0 g, 10.7 mmol) was heated in ethylene glycol (100 g) containing water (33 ml) and NaOH (10 g). After four hours at reflux, during which the nitrile dissolved and a solid formed, the mixture was cooled, diluted with water (400 ml), and acidified with acetic acid (100 ml). The precipitate was collected by filtration, and dried in vacuo to provide 7-([1,1'-biphenyl]-4-yloxy)heptanoic acid as a white solid (3.1 g 97% yield).

Provenance & Evidence