Ethanol → HCID 10084622, compound

HRID 974030Notes

Reaction equation

HRID 974030 reaction equation
[F:1][C:2]1[CH:7]=[C:6]([CH:8]([CH3:12])[C:9]([OH:11])=[O:10])[CH:5]=[CH:4][C:3]=1[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1.[CH2:19](O)[CH3:20]>>[CH2:19]([O:10][C:9](=[O:11])[CH:8]([C:6]1[CH:5]=[CH:4][C:3]([C:13]2[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=2)=[C:2]([F:1])[CH:7]=1)[CH3:12])[CH3:20]

Participants

3

Reactant 2

HCID 702EthanolHCID 3394Flurbiprofen

Product 1

HCID 10084622HCID 10084622, compound

Conditions

Temperature
50 °C

Procedure

To 2-(2-fluoro-4-biphenylyl)-propionic acid (30.0 g, 0.123 mol) in ethanol (300 ml) was added conc. sulfonic acid (3.0 g). After the addition, the mixture was stirring at 50° C. for 5 h, then concentrated and extracted with benzene. The benzene extracts were washed with aqueous sodium hydrogen carbonate solution then with water, and dried over. The extracts were evaporated under reduced pressure to afford ethyl-2-(2-fluoro-4-biphenylyl)propionate (33.6 g, 0.123 mol) as oily residue.

Workup

  1. additionAfter the addition
  2. concentrationconcentrated
  3. extractionextracted with benzene
  4. washThe benzene extracts were washed with aqueous sodium hydrogen carbonate solution
  5. dry with materialwith water, and dried over
  6. customThe extracts were evaporated under reduced pressure

Sources & evidence

ORD record
ord-a5dbfb5efde147ff8576b39b901a8dcd
Source dataset
uspto-grants-1991_11
Patent number
US05066666

Reaction notes

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