2-Pyridinecarbonitrile, 4-methoxy-3,5-dimethyl- → 3,5-Dimethyl-2-hydroxymethyl-4-methoxy-pyridine

HRID 974079Notes

Reaction equation

HRID 974079 reaction equation
[CH3:1][C:2]1[C:3]([C:11]#N)=[N:4][CH:5]=[C:6]([CH3:10])[C:7]=1[O:8][CH3:9].CC1C(CN)=NC=C(C)C=1[O:20]C>>[CH3:1][C:2]1[C:3]([CH2:11][OH:20])=[N:4][CH:5]=[C:6]([CH3:10])[C:7]=1[O:8][CH3:9]

Participants

3

Reactant 2

HCID 110737382-Pyridinecarbonitrile, 4-methoxy-3,5-dimethyl-HCID 14645997(4-Methoxy-3,5-dimethylpyridin-2-yl)methanamine

Product 1

HCID 7378233,5-Dimethyl-2-hydroxymethyl-4-methoxy-pyridine

Procedure

A process for the preparation of compounds of formula I ##STR1## in which X is the radical OH or Cl, by the catalytic hydrogenation of 3,5-dimethyl-4-methoxy-2-cyanopyridine, subsequent reaction of the resulting 3,5-dimethyl-4-methoxy-2-aminomethylpyridine to give 3,5-dimethyl-4-methoxy-2-hydroxymethylpyridine and, if desired, chlorination to give 3,5-dimethyl-4-methoxy-2-chloromethylpyridine, and the novel intermediate 3,5-dimethyl-4-methoxy-2-aminomethylpyridine.

Workup

  1. customA process for the preparation of compounds of formula I ##STR1## in which X

Sources & evidence

ORD record
ord-0be93686f6ea45979c298b01f99551cc
Source dataset
uspto-grants-1991_11
Patent number
US05066810

Reaction notes

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