反应详情

温度

40 °C

157.5 g (0.75 mol) of the 1,4-bisacetylamino-2-fluorobenzene obtained above under B. are initially introduced into 630 g of glacial acetic acid, and a mixture of 42 g of glacial acetic acid and 51 g of nitric acid (density 1.5) is added dropwise in the course of 2 hours. The mixture is subsequently stirred at 40° C. for a further 2 hours and cooled to 15° C. After the product which has precipitated has been filtered off, it is washed twice with 50 ml of glacial acetic acid each time and dried at 50° C. in a vacuum cabinet.

1. additionis added dropwise in the course of 2 hours
2. temperaturecooled to 15° C
3. customAfter the product which has precipitated
4. filtrationhas been filtered off
5. washit is washed twice with 50 ml of glacial acetic acid each time
6. customdried at 50° C. in a vacuum cabinet