Nitric Acid → HCID 14817082, compound

HRID 974147Notes

Reaction equation

HRID 974147 reaction equation
[C:1]([NH:4][C:5]1[CH:10]=[CH:9][C:8]([NH:11][C:12](=[O:14])[CH3:13])=[CH:7][C:6]=1[C:15]([F:18])([F:17])[F:16])(=[O:3])[CH3:2].[N+:19]([O-])([OH:21])=[O:20]>C(O)(=O)C>[C:12]([NH:11][C:8]1[CH:7]=[C:6]([C:15]([F:16])([F:17])[F:18])[C:5]([NH:4][C:1](=[O:3])[CH3:2])=[CH:10][C:9]=1[N+:19]([O-:21])=[O:20])(=[O:14])[CH3:13]

Participants

4

Reactant 2

HCID 944Nitric AcidHCID 759174HCID 759174, compound

Product 1

HCID 14817082HCID 14817082, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent2×

Procedure

91.5 g (0.3 mol) of 1,4-bisacetylamino-2-trifluoromethylbenzene (prepared according to B.) are initially introduced into 300 ml of glacial acetic acid, and a mixture of 25 g of glacial acetic acid and 20 g of nitric acid (density 1.5) is added dropwise at 50° C. in the course of 60 minutes. The mixture is subsequently stirred at the same temperature for 12 hours and then poured onto 2.5 kg of ice. The product which has precipitated is filtered off with suction, washed with water and dried.

Workup

  1. additionis added dropwise at 50° C. in the course of 60 minutes
  2. customThe product which has precipitated
  3. filtrationis filtered off with suction
  4. washwashed with water
  5. customdried

Sources & evidence

ORD record
ord-7a78973cceaa42b0ac808ac534dd321d
Source dataset
uspto-grants-1991_11
Patent number
US05067967

Reaction notes

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