Methylamine → HCID 14476568, compound

Participants

Reaction Steps

8.2 g of the product of Step A were dissolved in 82 ml of tetrahydrofuran and 7 ml of triethylamine and after the mixture was cooled in a bath to -20° C., 3.9 ml of methane sulfonyl chloride in solution in 8 ml of tetrahydrofuran were added. After returning to ambient temperature, 35 ml of methylamine at 33% in ethanol were added and the mixture was stirred for 23 hours. The solvents were eliminated under reduced pressure and 150 ml of water and 10 ml of a solution of sodium hydroxide were added. Extraction was effected with methylene chloride and the extracts were washed with salted water, dried, filtered and concentrated to dryness under reduced pressure to obtain 8.7 g of the expected products as an orange-colored oil.

Provenance & Evidence