HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → Tert-butyl 4-ethynylbenzoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | tert-Butyl 4-((trimethylsilyl)ethynyl)benzoate | HCID 13965007 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | Tert-butyl 4-ethynylbenzoate | HCID 13965008 | 95.9% |
Reaction Steps
274.4 g of 4-(trimethylsilylethinyl)-benzoic acid tert.-butyl ester and 12.5 g of anhydrous potassium carbonate in 1.5 l of absolute methanol are stirred together for 3 hours under nitrogen. The reaction mixture is then concentrated by evaporation and worked up with CH2Cl2 /H2O to yield 194 g of 4-ethinyl-benzoic acid tert.-butyl ester.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05068300 |
| Source dataset | uspto-grants-1991_11 |
| ORD ID | ord-39fd856448a04295a5c1912c3375a7ac |
| Source note | uspto-grants-1991_11 |