HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 974220Generated: October 30, 2026
1-Bromo-2-iodobenzene → 4-Bromotolan-4'-carboxylic acid-tert.-butyl ester
https://huagongshe.com/reaction/974220
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 1-Bromo-2-iodobenzene | HCID 11415 | — |
| Reactant | Triphenylphosphine | HCID 11776 | — |
| Reactant | Tert-butyl 4-ethynylbenzoate | HCID 13965008 | — |
| Catalyst | Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI) | HCID 24350 | — |
| Catalyst | HCID 178418476 | HCID 178418476 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Solvent | Diethylamine | HCID 8021 | — |
| Product | 4-Bromotolan-4'-carboxylic acid-tert.-butyl ester | HCID 67931866 | — |
Reaction Steps
2.8 g (Ph3P)2PdCl2 and 400 mg of CuI are added to a solution of 40.4 g of 4-ethinyl-benzoic acid tert.-butyl ester, 56.6 g of bromoiodobenzene and 1.34 g of Ph3P in 50 ml of diethylamine and 300 ml of absolute acetonitrile and the reaction mixture is stirred for 72 hours at 40° C., suction filtered and dried.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US05068300 |
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| Source dataset | uspto-grants-1991_11 |
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| ORD ID | ord-888987550c094b79965c4cfa1e2713d9 |
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| Source note | uspto-grants-1991_11 |
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