HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl iodide → 1-Methyl-7,8-dihydroquinoline-2,5(1H,6H)-dione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl iodide | HCID 6328 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 2-Hydroxy-7,8-dihydro-5(6H)-quinolinone | HCID 267450 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 1-Methyl-7,8-dihydroquinoline-2,5(1H,6H)-dione | HCID 10442242 | — |
Reaction Steps
3.36 g (0.0206 mol) of 7,8-dihydro-2,5(1H,6H)-quinolinedione are stirred with 5.69 g (2×0.0206 mol) of powdered anhydrous potassium carbonate and 1.92 ml (1.5×0.0206 mol) of methyl iodide in 35 ml of dimethylformamide for 16 hours at ambient temperature. The mixture is then suction filtered, the solvent is evaporated off in vacuo and the residue is recrystallised from chloroform/ethyl acetate. Melting point: 203°-205° C., Yield: 3.1 g (84.9% of theory).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05068334 |
| Source dataset | uspto-grants-1991_11 |
| ORD ID | ord-cbe45208940749aeb179dd236699155a |
| Source note | uspto-grants-1991_11 |