Ammonia → HCID 12665890, compound

HRID 974231Notes

Reaction equation

HRID 974231 reaction equation
[CH3:1][C:2]1[C:11]2[C:10](=[O:12])[CH2:9][CH2:8][CH2:7][C:6]=2[O:5][C:4](=O)[CH:3]=1.[NH3:14]>>[CH3:1][C:2]1[C:11]2[C:10](=[O:12])[CH2:9][CH2:8][CH2:7][C:6]=2[NH:14][C:4](=[O:5])[CH:3]=1

Participants

3

Reactant 2

HCID 222AmmoniaHCID 12333358HCID 12333358, compound

Product 1

HCID 12665890HCID 12665890, compound

Procedure

4.46 g (0.025 mol) of 4-methyl-5,6,7,8-tetrahydro- cumarin-5-one are heated to 180° C. for 3 hours in 150 ml of saturated methanolic ammonia in a stirred autoclave. After cooling, the methanolic ammonia is distilled off using a rotary evaporator and the residue is recrystallised from ethanol using activated charcoal.

Workup

  1. temperatureAfter cooling
  2. distillationthe methanolic ammonia is distilled off
  3. customa rotary evaporator
  4. customthe residue is recrystallised from ethanol using activated charcoal

Sources & evidence

ORD record
ord-6a5f205e0a874e37aae5f11b4236c442
Source dataset
uspto-grants-1991_11
Patent number
US05068334

Reaction notes

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