Chlorobenzene → HCID 13747117, compound

Participants

Reaction Steps

A mixture of 4-(2,3-dichlorophenyl)-1,4-dihydro-6-methyl-2-(2-dimethylaminoethyl)pyridine 3,5-dicarboxylic acid dimethyl ester (2.14 g, 5mmol), 2-methylimidazole (1.64 g, 20mmol), 1,8-diazabicyclo[5.4.0]undec-7-ene (0.75 g, 5mmol) and chlorobenzene (50ml) was heated at reflux for 24hours. The solution was cooled, diluted with chloroform (25ml), washed with water (100ml), dried and evaporated. The residue was chromatographed on silica gel (50 g, Act I) using chloroform-methanol as eluent to give the title compound. This was suspended in methanol (10ml) and acidified by addition of maleic acid (0.5 g, 5% excess) to give a clear solution which was then diluted with ether (10ml) to precipitate the crystalline maleate salt 1.65 g mp 197°-198°.

Provenance & Evidence