Methyl 2-((3-nitrophenyl)methylene)-3-oxobutanoate → HCID 67928278, compound

HRID 974277Notes

Reaction equation

HRID 974277 reaction equation
[N+:1]([C:4]1[CH:5]=[C:6]([CH:16]=[CH:17][CH:18]=1)[CH:7]=[C:8]([C:13]([CH3:15])=O)[C:9]([O:11][CH3:12])=[O:10])([O-:3])=[O:2].[NH2:19]/[C:20](/[CH2:29][N:30]1[CH:34]=[CH:33][N:32]=[CH:31]1)=[CH:21]\[C:22]([O:24][CH2:25][CH2:26][O:27][CH3:28])=[O:23]>C(O)C>[CH3:12][O:11][C:9]([C:8]1[CH:7]([C:6]2[CH:16]=[CH:17][CH:18]=[C:4]([N+:1]([O-:3])=[O:2])[CH:5]=2)[C:21]([C:22]([O:24][CH2:25][CH2:26][O:27][CH3:28])=[O:23])=[C:20]([CH2:29][N:30]2[CH:34]=[CH:33][N:32]=[CH:31]2)[NH:19][C:13]=1[CH3:15])=[O:10]

Participants

4

Reactant 2

HCID 1536427Methyl 2-((3-nitrophenyl)methylene)-3-oxobutanoateHCID 19986033HCID 19986033, compound

Product 1

HCID 67928278HCID 67928278, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of methyl 2-(3-nitrobenzylidene)-acetoacetate (2.5 g, 0.01 mol), ethanol (20 ml) and 2-methoxyethyl 3-amino-4-(imidazol-1-yl)crotonate (3 g) is heated at reflux for 5 hours to give the title compound.

Workup

  1. temperatureis heated
  2. temperatureat reflux for 5 hours

Sources & evidence

ORD record
ord-ac24a9a71b774922bd241117f6766417
Source dataset
uspto-grants-1991_11
Patent number
US05068337

Reaction notes

Loading…