Acetic Anhydride → HCID 19985779, compound

HRID 974285Notes

Reaction equation

HRID 974285 reaction equation
[NH2:1][C:2]1[S:3][C:4]2[CH2:5][CH2:6][N:7]([CH2:12][C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=3)[CH2:8][CH2:9][C:10]=2[N:11]=1.C1(N)C(F)=C(F)C(F)=C(N)C=1F.Cl.Cl.[C:33](OC(=O)C)(=[O:35])[CH3:34]>>[C:33]([NH:1][C:2]1[S:3][C:4]2[CH2:5][CH2:6][N:7]([CH2:12][C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=3)[CH2:8][CH2:9][C:10]=2[N:11]=1)(=[O:35])[CH3:34]

Participants

4

Reactant 3

HCID 7918Acetic AnhydrideHCID 149026Tetrafluoro-m-phenylenediamine dihydrochlorideHCID 19985880HCID 19985880, compound

Product 1

HCID 19985779HCID 19985779, compoundYield 62%

Procedure

Prepared from 2-amino-6-benzyl-4,5,7,8-tetrahydro-6H-thiazolo[5,4-d]azepine (see Example 4 in GB-A-1321509, melting point of the dihydrochloride 232° C.) and 1.2 equivalents of acetic anhydride by refluxing for 2 hours. Yield: 62% of theory, Melting point: 129°-130° C.

Workup

  1. temperatureby refluxing for 2 hours

Sources & evidence

ORD record
ord-1bde265c54f64882a050c10abf28790a
Source dataset
uspto-grants-1991_11
Patent number
US05068325

Reaction notes

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