HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diethyl Ether → 2-Amino-6-(3-(4-methyl-phenyl)allyl)-4,5,7,8-tetrahydro-6H-thiazolo[5,4-d]azepine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diethyl Ether | HCID 3283 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 2-Amino-4,5,6,7,8-pentahydrothiazolo[5,4-d]azepine | HCID 19985785 | — |
| Reactant | 1-(3-Chloroprop-1-en-1-yl)-4-methylbenzene | HCID 54205675 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | 2-Amino-6-(3-(4-methyl-phenyl)allyl)-4,5,7,8-tetrahydro-6H-thiazolo[5,4-d]azepine | HCID 54337058 | 33% |
Reaction Steps
Prepared from 4-methyl-cinnamyl chloride and 1 equivalent of 2-amino-4,5,7,8-tetrahydro-6H-thiazolo[5,4-d]azepine in acetonitrile in the presence of 1 equivalent of potassium carbonate for 40 minutes at 80° C. Yield: 33% of theory, Melting point: 126°-30° C. (ether).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05068325 |
| Source dataset | uspto-grants-1991_11 |
| ORD ID | ord-06046273250a4094b107712d9c8bb1c4 |
| Source note | uspto-grants-1991_11 |