2-Amino-4,5,6,7,8-pentahydrothiazolo[5,4-d]azepine → HCID 53923731, compound

HRID 974301Notes

Reaction equation

HRID 974301 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:10]=[C:11]([O:13][CH3:14])[CH:12]=1)[CH:6]=[CH:7][CH2:8]Cl.[NH2:15][C:16]1[S:17][C:18]2[CH2:19][CH2:20][NH:21][CH2:22][CH2:23][C:24]=2[N:25]=1>C(Cl)(Cl)Cl>[NH2:15][C:16]1[S:17][C:18]2[CH2:19][CH2:20][N:21]([CH2:8][CH:7]=[CH:6][C:5]3[CH:4]=[C:3]([O:2][CH3:1])[CH:12]=[C:11]([O:13][CH3:14])[CH:10]=3)[CH2:22][CH2:23][C:24]=2[N:25]=1

Participants

4

Reactant 2

HCID 199857852-Amino-4,5,6,7,8-pentahydrothiazolo[5,4-d]azepineHCID 54244610HCID 54244610, compound

Product 1

HCID 53923731HCID 53923731, compoundYield 21%

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

Prepared from 3,5-dimethoxy-cinnamyl chloride and 2 equivalents of 2-amino-4,5,7,8-tetrahydro-6H-thiazolo[5,4-d]azepine in chloroform. Yield 21% of theory, Melting point: 114°-19° C. (petroleum ether).

Sources & evidence

ORD record
ord-bf68e2eec1c2418a95a4be84fcfad769
Source dataset
uspto-grants-1991_11
Patent number
US05068325

Reaction notes

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