Diethyl Ether → HCID 53851148, compound

HRID 974309Notes

Reaction equation

HRID 974309 reaction equation
[F:1][C:2]1[CH:11]=[CH:10][CH:9]=[CH:8][C:3]=1[CH:4]=[CH:5][CH2:6]Cl.[NH2:12][C:13]1[S:14][C:15]2[CH2:16][CH2:17][NH:18][CH2:19][CH2:20][C:21]=2[N:22]=1.CCOCC>C(Cl)(Cl)Cl>[NH2:12][C:13]1[S:14][C:15]2[CH2:16][CH2:17][N:18]([CH2:6][CH:5]=[CH:4][C:3]3[CH:8]=[CH:9][CH:10]=[CH:11][C:2]=3[F:1])[CH2:19][CH2:20][C:21]=2[N:22]=1

Participants

5

Reactant 3

HCID 3283Diethyl EtherHCID 199857852-Amino-4,5,6,7,8-pentahydrothiazolo[5,4-d]azepineHCID 53876605HCID 53876605, compound

Product 1

HCID 53851148HCID 53851148, compoundYield 36%

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

Prepared from 2-fluoro-cinnamyl chloride and 2 equivalents of 2-amino-4,5,7,8-tetrahydro-6H-thiazolo-[5,4-d]azepine in chloroform. Yield: 36% of theory, Melting point: 96°-102° C. (ether).

Sources & evidence

ORD record
ord-431d05ecaa634c578c6337bd61d410d8
Source dataset
uspto-grants-1991_11
Patent number
US05068325

Reaction notes

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