Diethyl Ether → HCID 54547081, compound

HRID 974310Notes

Reaction equation

HRID 974310 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:9]=[CH:10][CH:11]=1)[CH:5]=[CH:6][CH2:7]Cl.[NH2:12][C:13]1[S:14][C:15]2[CH2:16][CH2:17][NH:18][CH2:19][CH2:20][C:21]=2[N:22]=1.CCOCC>C(Cl)(Cl)Cl>[NH2:12][C:13]1[S:14][C:15]2[CH2:16][CH2:17][N:18]([CH2:7][CH:6]=[CH:5][C:4]3[CH:9]=[CH:10][CH:11]=[C:2]([F:1])[CH:3]=3)[CH2:19][CH2:20][C:21]=2[N:22]=1

Participants

5

Reactant 3

HCID 3283Diethyl EtherHCID 199857852-Amino-4,5,6,7,8-pentahydrothiazolo[5,4-d]azepineHCID 53945297HCID 53945297, compound

Product 1

HCID 54547081HCID 54547081, compoundYield 44%

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

Prepared from 3-fluoro-cinnamyl chloride and 2 equivalents of 2-amino-4,5,7,8-tetrahydro-6H-thiazolo[5,4-d]azepine in chloroform. Yield: 44% of theory, Melting point: 128°-132° C. (ether).

Sources & evidence

ORD record
ord-fe8a3ce6acb249ac9c29df0bf6c019ff
Source dataset
uspto-grants-1991_11
Patent number
US05068325

Reaction notes

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