2-Amino-4,5,6,7,8-pentahydrothiazolo[5,4-d]azepine → HCID 54512929, compound

HRID 974311Notes

Reaction equation

HRID 974311 reaction equation
[F:1][C:2]1[CH:11]=[CH:10][C:5]([CH:6]=[CH:7][CH2:8]Cl)=[CH:4][CH:3]=1.[NH2:12][C:13]1[S:14][C:15]2[CH2:16][CH2:17][NH:18][CH2:19][CH2:20][C:21]=2[N:22]=1>C(Cl)(Cl)Cl>[NH2:12][C:13]1[S:14][C:15]2[CH2:16][CH2:17][N:18]([CH2:8][CH:7]=[CH:6][C:5]3[CH:10]=[CH:11][C:2]([F:1])=[CH:3][CH:4]=3)[CH2:19][CH2:20][C:21]=2[N:22]=1

Participants

4

Reactant 2

HCID 199857852-Amino-4,5,6,7,8-pentahydrothiazolo[5,4-d]azepineHCID 536642611-(3-Chloro-1-propen-1-yl)-4-fluorobenzene

Product 1

HCID 54512929HCID 54512929, compoundYield 13%

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

Prepared from 4-fluoro-cinnamyl chloride and 2 equivalents of 2-amino-4,5,7,8-tetrahydro-6H-thiazolo[5,4-d]azepine in chloroform. Yield: 13% of theory, Melting point: 142°-146° C.

Sources & evidence

ORD record
ord-d35d91a32cc84b218ec2f3a0ac978aff
Source dataset
uspto-grants-1991_11
Patent number
US05068325

Reaction notes

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