Diethyl Ether → HCID 53856336, compound

HRID 974315Notes

Reaction equation

HRID 974315 reaction equation
[CH3:1][S:2]([C:5]1[CH:14]=[CH:13][C:8]([CH:9]=[CH:10][CH2:11]Cl)=[CH:7][CH:6]=1)(=[O:4])=[O:3].[NH2:15][C:16]1[S:17][C:18]2[CH2:19][CH2:20][NH:21][CH2:22][CH2:23][C:24]=2[N:25]=1.CCOCC>C(Cl)(Cl)Cl>[NH2:15][C:16]1[S:17][C:18]2[CH2:19][CH2:20][N:21]([CH2:11][CH:10]=[CH:9][C:8]3[CH:13]=[CH:14][C:5]([S:2]([CH3:1])(=[O:4])=[O:3])=[CH:6][CH:7]=3)[CH2:22][CH2:23][C:24]=2[N:25]=1

Participants

5

Reactant 3

HCID 3283Diethyl EtherHCID 199857852-Amino-4,5,6,7,8-pentahydrothiazolo[5,4-d]azepineHCID 53759175HCID 53759175, compound

Product 1

HCID 53856336HCID 53856336, compoundYield 21%

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

Prepared from 4-methylsulphonyl-cinnamyl chloride and 2 equivalents of 2-amino-4,5,7,8-tetrahydro-6H-thiazolo[5,4-d]azepine in chloroform. Yield: 21% of theory, Melting point: 157°-161° C. (ether).

Sources & evidence

ORD record
ord-a68d746cb4034d689518eff577044d3a
Source dataset
uspto-grants-1991_11
Patent number
US05068325

Reaction notes

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