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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 974319Generated: October 27, 2026

1-(3-Bromopropyl)-4-chlorobenzene → 2-Amino-6-(3-4-chlorophenyl)propyl-4,5,7,8-tetrahydro-6H-thiazolo[5,4-d]azepine

https://huagongshe.com/reaction/974319

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-(3-Bromopropyl)-4-chlorobenzeneHCID 9881136—
Reactant2-Amino-4,5,6,7,8-pentahydrothiazolo[5,4-d]azepineHCID 19985785—
SolventDimethylformamideHCID 6228—
Product2-Amino-6-(3-4-chlorophenyl)propyl-4,5,7,8-tetrahydro-6H-thiazolo[5,4-d]azepineHCID 1998581637%

Reaction Steps

Prepared from 3-(4-chlorophenyl)propyl bromide and 2 equivalents of 2-amino-4,5,7,8-tetrahydro-6H-thiazolo[5,4-d]azepine in anhydrous dimethylformamide. Yield: 37% of theory, Melting point: 153° C.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05068325
Source datasetuspto-grants-1991_11
ORD IDord-474f57415d6b48e091e29a814c157049
Source noteuspto-grants-1991_11