HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium cyanoborohydride → HCID 53856827, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium cyanoborohydride | HCID 5003444 | — |
| Reactant | 2-Amino-4,5,6,7,8-pentahydrothiazolo[5,4-d]azepine | HCID 19985785 | — |
| Reactant | 3-(1H-Indol-3-yl)prop-2-enal | HCID 54058845 | — |
| Product | HCID 53856827 | HCID 53856827 | 11% |
Reaction Steps
Prepared from 3-(3-indolyl)acrolein and 1 equivalent of 2-amino-4,5,7,8-tetrahydro-6H- thiazolo[5,4-d]azepine by reductive amination with 0.9 equivalents of sodium cyanoborohydride. Purification of the crude product by column chromatography is carried out using neutral aluminium oxide of activity stage I (toluene/ethyl acetate/ethanol=4:1:0.5). Yield: 11% of theory, Melting point: 155°-160° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05068325 |
| Source dataset | uspto-grants-1991_11 |
| ORD ID | ord-c7ee4d8ae7cc473cbb94a2f9f3c309ea |
| Source note | uspto-grants-1991_11 |